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Therapeutic target database update 2022: facilitating …

WebDrug discovery relies on the knowledge of not only drugs and targets, but also the comparative agents and targets. These include poor binders and non-binders for …

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A five-day course of ivermectin for the treatment of …

WebIvermectin, a US Food and Drug Administration-approved anti-parasitic agent, was found to inhibit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication in …

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Genome-wide programmable transcriptional memory by …

WebA general approach for heritably altering gene expression has the potential to enable many discovery and therapeutic efforts. Here, we present CRISPRoff-a …

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Innate immune suppression by SARS-CoV-2 mRNA …

WebThe mRNA SARS-CoV-2 vaccines were brought to market in response to the public health crises of Covid-19. The utilization of mRNA vaccines in the context of infectious disease …

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Low-dose naltrexone (LDN): A promising treatment in immune …

WebIn recent years, there have been some novel and significant findings on the off-label usage of naltrexone. Within a specific dosage window, LDN can act as an immunomodulator in …

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Long non-coding RNAs: From disease code to drug role

WebCutting-edge strategies for lncRNA modulation have been summarized, including the sources of lncRNA-related drugs, such as genetic technology and small-molecule …

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Statistical Significance

WebIn research, statistical significance is a measure of the probability of the null hypothesis being true compared to the acceptable level of uncertainty regarding the true …

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Change-of-Shift Nursing Handoff Interruptions: Implications for

WebChange-of-shift handoff is an important source of data used in surveillance, a nursing intervention aimed at identifying and preventing complications. Surveillance requires the …

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Distinct and Dynamic ON and OFF Neural Ensembles in …

WebWe further illustrated that ON and OFF ensembles tuned to social exploration carried information of salience and novelty for social targets. Finally, we …

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Reducing medication errors for adults in hospital settings

WebLow-certainty evidence suggests that, compared to MR by other professionals, MR by pharmacists may reduce medication errors (OR 0.21, 95%CI 0.09 …

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Immune-Related Adverse Events (irAEs): Diagnosis, …

WebAbstract. Purpose of review: While immune checkpoint inhibitor (ICI) therapy has improved melanoma patient outcomes, it has also resulted in the rise of unique …

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Kinrix: a new combination DTaP-IPV vaccine for children aged 4

WebRecently, a combined diphtheria toxoid, tetanus toxoid, acellular pertussis and inactivated poliomyelitis vaccine (DTaP-IPV), Kinrix, has been licensed in the USA for use as the …

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Neutrophil-to-lymphocyte ratio, past, present and future …

WebNLR is cheap, simple, fast responding and easy available parameter of stress and inflammation with high sensitivity and low specificity, it should be used routinely in …

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First-Line Nivolumab Plus Ipilimumab in Advanced NSCLC: 4-Year …

WebAt more than 4 years' minimum follow-up, with all patients off immunotherapy treatment for at least 2 years, first-line nivolumab plus ipilimumab continued to demonstrate durable …

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Targeting cancer metabolism in the era of precision oncology

WebHence, the conceptual framework for drug design must consider the metabolic vulnerabilities of non-cancer cells in the tumour immune microenvironment, as well as those of cancer …

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Decline in the mental health of nurses across the globe during

WebBackground: Nurses represent the major proportion of frontline health care professionals delivering 24/7 services to patients with an increased vulnerability towards …

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PD-L1 expression by Tumor Proportion Score (TPS) and Combined …

WebBackground: For non-small cell lung cancer (NSCLC) the most used method for analysing programmed cell death ligand 1 (PD-L1) expression is the Tumor Proportion Score …

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Immune Responses in the Liver

WebThe liver is a key, frontline immune tissue. Ideally positioned to detect pathogens entering the body via the gut, the liver appears designed to detect, capture, …

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