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On determining the most appropriate test cut-off value: …

As the cut-off value decreases, the test Se increases and Sp decreases, moving on the curve from the left-lower corner up and to the right to ultimately reach the right-upper corner of the square where Se = 1 and Sp = 0, corresponding to the lowest possible test cut-off value. In theory, we can think of a continuous curve with infinite number

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Financial Eligibility Criteria and Medication Coverage for …

Drugs were identified for subgroup analysis that had any use reported on the Medicare Part D spending dashboard and any off-patent brand-name drugs that incurred …

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Mock Code: A Code Blue Scenario Requested by and …

The use of simulation in medical training is quickly becoming more common, with applications in emergency, surgical, and nursing education. Recently, registered nurses …

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Off-Label Prescribing: A Call for Heightened Professional …

Off-label prescribing is an integral part of contemporary medicine. Many patients benefit when they receive drugs or devices under circumstances not specified on the label approved by the …

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Off-label Medication Prescribing Patterns in Pediatrics: An …

Off-label drug use is defined as use in a patient younger than the lower limit of the FDA-approved age range for any indication or dosage form of that drug. Results: At least 1 drug was …

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Methylphenidate off-label use and safety

There were 38 adults (20 men, 18 women), of which 32 (88%) off-label use. In adults, methylphenidate was prescribed for depression, and this practice was associated with …

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Mechanical Properties of Fibre Reinforced Polymers under …

By testing GFRP tensile coupons under transient and steady-state thermal conditions at temperatures from ambient to 200 °C, Chowdhury et off-shore rigs, panel walls, trains, trail …

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A Clinical Overview of Off-label Use of Gabapentinoid Drugs

Observations: This report summarizes the limited published evidence to support off-label gabapentinoid uses, describes clinical cases in which off-label use is problematic, …

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Cigarette smoking and reasons for leaving school among …

A coupon system was used to keep track of the RDS recruitment chain. Each respondent received three coupons and invitation cards to recruit three other school dropouts …

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Off-label Prescribing Trends for ADHD Medications in Very Young

Objective: This study examines off-label medication prescribing use and trends in children on Medicaid with ADHD with particular focus on the very young (under age 6 years). Methods: …

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Ten Common Questions (and Their Answers) About Off-label Drug …

The term off-label drug use (OLDU) is used extensively in the medical literature, continuing medical education (CME) exercises, and the media. It is a polarizing term because it can be …

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The on-off phenomenon

The on-off phenomenon is an almost invariable consequence of sustained levodopa treatment in patients with Parkinson's disease. Phases of immobility and incapacity associated with …

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Avoidance of On-Target Off-Tumor Activation Using a Co …

Chimeric antigen receptors (CARs) combine T cell activation with antibody-mediated tumor antigen specificity, bypassing the need for T cell receptor (TCR) ligation. A limitation of CAR …

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Waging War on Poverty: Poverty Trends Using a Historical …

The WIC program, which provides coupons that can be used to purchase healthy food by low-income pregnant women and women with infants and toddlers, was established as a pilot …

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Acidithiobacillus ferrianus sp. nov.: an ancestral extremely

Sulfur coupons were prepared as described by Castro et al. . Samples were critical point dried, coated with gold and observed with a LEO 1420VP scanning electron microscope. For …

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Prescription Pattern of Antidepressants for Children and …

By the Korean MFDS standards, off-label prescriptions comprised 72.3% of OCD treatment and 14.4% of enuresis treatment. For all the other diagnoses including depressive …

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Prescribing gabapentin off label: Perspectives from psychiatry, pain

Methods: We used a case study approach to explore the experiences of physicians prescribing gabapentin for off-label indications. Semi-structured interviews were conducted with 10 …

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Optimized sgRNA design to maximize activity and minimize off …

Abstract. CRISPR-Cas9-based genetic screens are a powerful new tool in biology. By simply altering the sequence of the single-guide RNA (sgRNA), one can reprogram Cas9 to target …

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