Selegiline improved ''end-of-dose'' fluctuations in 50-63% of patients and early morning akinesia in 56% of patients treated in several studies. In clinical studies, selegiline improved mild ''on-off'' disabilities and freezing; however, selegiline is not useful in the management of severe ''on-off'' oscillations.

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CARBIDOPA-LEVODOPA 25-100 TAB (Generic Sinemet)

In the ''on-off'' phenomenon, a sudden loss of effectiveness with an abrupt onset of akinesia (''off'' effect) which may last from 1 minute to an hour followed by an equally sudden return of effectiveness (''on'' effect) may occur many times daily. This occasionally can be …

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ESTRADIOL-NORETH 1-0.5 MG TAB (Generic Activella, Amabelz

If the system is off for longer than one day or for an unknown duration, a new system should be applied immediately and a new 4-week cycle should be started; a back-up method of contraception (e.g., condoms, spermicides, diaphragm) must be used for the first week of the new cycle. Patients should be instructed to handle the used transdermal

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The dosage of the inhalation aerosol fixed-combination preparation (Advair HFA) is 42 mcg of salmeterol and 90, 230, or 460 mcg of fluticasone propionate (2 inhalations) twice daily, given approximately 12 hours apart (morning and evening). The maximum recommended dosage of salmeterol is 42 mcg in fixed combination with 460 mcg of fluticasone

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estradiol 0.075 mg patch generic alora, minivelle, vivelle

Commercially available estradiol 0.06% topical gel (EstroGel) is supplied in a non-aerosol metered-dose pump. Each depression of the pump delivers 1.25 g of gel containing 0.75 mg of estradiol. When estradiol gel (EstroGel) is used for the management of moderate to severe vasomotor symptoms associated with menopause or the treatment of moderate

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